How can you increase the half life of a drug?
Half life is increased by an increase in the volume of distribution and increased by a decrease in the rate of clearance. In some disease states (eg.
What is meant by terminal half life?
A parameter frequently used to describe the result of a pharmacokinetic. experiment is the terminal half-life of a drug. The terminal half-life is defined. as the time required for the plasma concentration of a drug to decrease. 50% in the final stage of its elimination; this parameter is also called the.
What medication route has the slowest absorption rate?
Subcutaneous (SC) The absoroption of subcutaneous injections is slower than that of IV route and it needs absorption similar to Intramuscular injection.
Which is the major process of absorption for more than 90% of drugs?
Which is the major process of absorption for more than 90% of drugs? Explanation: Passive diffusion is also known as non-ionic diffusion. It is the major process through which 90% of the drugs get absorbed.
Why are ionized drugs poorly distributed?
Most drugs are weak acids or bases that are present in solution as both the ionized and unionized forms. Ionized molecules are usually unable to penetrate lipid cell membranes because they are hydrophilic and poorly lipid soluble.
How do you increase lipophilicity of a drug?
Lipophilicity of drugs/carriers can be enhanced by reducing their hydrogen-bonding potential and by the addition of lipophilic groups.
What are the factors affecting absorption of drugs?
Factors affecting absorption of drugs
- Disintegration Time.
- Dissolution Time.
- Manufacturing variables.
- Pharmaceutical Ingredient.
- Nature /type of dosage form.
- Product age and storage condition.
Why Most drugs are weak acids or weak bases?
Most of the drugs are available as weak acids or weak bases. The weak base is absorbed at a faster rate from the intestine (pH 7.50 – 8), this is because the basic substances can’t be ionized in basic medium. So the uncharged substances can be passed easily due to its lipid solubility.
How do you know if a drug is a weak acid or base?
The only sure way to know whether a drug is acidic or basic is to learn the functional groups that confer acidity and basicity on a molecule. This should be done even if it means learning the names of the functional groups the way you learned multiplication tables at primary school.