Why are you not supposed to eat grapefruit with cholesterol medicine?

Why are you not supposed to eat grapefruit with cholesterol medicine?

Grapefruit contains a chemical that can interfere with your body’s ability to break down or metabolize certain statin medications. When statin takers eat large amounts of grapefruit, the level of statins in their blood can increase, raising the possibility of side effects.

What happens if you eat grapefruit with cholesterol medicine?

With some statins, drinking grapefruit juice, or eating grapefruit, is a bad idea. Grapefruit juice can cause that statin to stay in your body much longer, and the drug can build up. This can increase the risk of muscle breakdown, liver damage, and even kidney failure.

What time of day should I take my fenofibrate?

You should take fenofibrate with food, so taking your doses during a mealtime is ideal. This is because fenofibrate is absorbed better by your body when there is some food in your stomach. Some people find it helps to swallow the tablet/capsule with a drink of water.

Is it OK to drink alcohol while taking fenofibrate?

What should I avoid while taking fenofibrate? Avoid eating foods high in fat or cholesterol, or fenofibrate will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

Is fenofibrate bad for the liver?

Fenofibrate can cause abnormal results in tests of liver function. These abnormal results can indicate liver damage. This drug can also cause other liver damage and inflammation after years of use.

How long does it take for fenofibrate to lower triglycerides?

Takes about a week for levels to stabilize. May take several weeks before effects on cholesterol and triglycerides levels are apparent. Fenofibrate lowers total cholesterol by 9 to 13%, VLDL cholesterol by 44 to 49%, triglycerides by 46 to 54%, and apolipoprotein B (Apo B).

Will I lose weight taking fenofibrate?

Recently, several studies have examined the effects of PPARα agonists on energy intake, body weight, and body fat in rodent models of obesity. In selectively bred obese-prone rats, fenofibrate (100 mg/kg per day) reduced body weight gain, adiposity, food intake, and feed efficiency [2].

What are the long term side effects of fenofibrate?

• Chronic indigestion.
• dark urine.
• muscle cramps, spasms, stiffness, swelling, or weakness.
• troubled breathing.
• unusual bleeding or bruising.
• yellow eyes or skin.

Does fenofibrate cause memory loss?

For women but not men, fibrate use was specifically associated with an increased risk over 7 years of decline in visual memory only (HR=1.29, 95%CI=1.09–1.54, p=0.004), and did not increase risk for incident dementia.

Can fenofibrate hurt your kidneys?

Conclusion: Short-term fenofibrate treatment did not alter glomerular filtration rate by more than 20% in subjects with normal kidney function, but a smaller decrease cannot be ruled out. Increased serum creatinine levels may be caused by decreased creatinine clearance.

Is fenofibrate safe for kidneys?

Fenofibrate is known to increase serum creatinine, but this effect is fully reversible, even after long-term treatment. The mechanism underlying this is poorly understood, but fenofibrate is not thought to impair true glomerular function, as measured by inulin clearance, the gold standard measure of renal function.

What is a substitute for fenofibrate?

(fenofibrate)

• Antara (fenofibrate) Prescription only.
• 8 alternatives.
• Niaspan (niacin) Prescription only.
• Trilipix (fenofibric acid) Prescription only.
• Omega 3 Acid (omega-3 acid) Prescription only.
• Vytorin (ezetimibe / simvastatin) Prescription only.
• Crestor (rosuvastatin) Prescription only.
• Atorvastatin (atorvastatin)

What does fenofibrate do for the body?

Fenofibrate is used with a low-fat diet, exercise, and sometimes with other medications to reduce the amounts of fatty substances such as cholesterol and triglycerides in the blood and to increase the amount of HDL (high-density lipoprotein; a type of fatty substance that decreases the risk of heart disease) in the …

Can fenofibrate cause increased creatinine levels?

Fenofibrate is a potent hypolipemic agent, widely used in patients with renal insufficiency in whom dyslipidemia is frequent. A moderate reversible increase in creatinine plasma levels is an established side effect of fenofibrate therapy, which mechanism remains unknown.

Why is fenofibrate contraindicated in hemodialysis?

The patients with end-stage renal disease treated with hemodialysis may be particularly susceptible to toxic effects of fibrates since in the absence of the removal of their metabolites with urine only about 10% of a single fenofibrate dose was cleared from the blood by hemodialysis resulting in a substantially …

How do you lower creatinine levels?

Here are 8 ways to naturally lower your creatinine levels.

1. Don’t take supplements containing creatine.
2. Reduce your protein intake.
3. Eat more fiber.
4. Talk with your healthcare provider about how much fluid you should drink.
5. Lower your salt intake.
6. Avoid overusing NSAIDs.
7. Avoid smoking.
8. Limit your alcohol intake.

Does fenofibrate lower blood pressure?

Fenofibrate reduces blood pressure, heart rate and renal vasoconstriction in salt-sensitive volunteers, but not in salt-resistant volunteers.

Is fenofibrate good for cholesterol?

Fenofibrate is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It works by increasing the natural substance (enzyme) that breaks down fats in the blood.

Can you take fenofibrate with blood pressure medicine?

RESULTS—Fenofibrate, combined therapy, or candesartan therapy significantly reduced blood pressure. However, combined therapy significantly reduced blood pressure more than fenofibrate or candesartan alone (P < 0.001 by ANOVA).