Does translocation affect sperm?
Chromosomal translocations may cause reductions in testicular volume and testosterone level, which may impact spermatogenesis, resulting in azoospermia or oligozoospermia and male infertility.
How does translocation affect fertility?
Translocations are the most common type of chromosomal structural anomalies. Chromosomal translocations are known to reduce fertility in men and women. A study of 1056 infertile men showed that 16.1% had chromosomal abnormalities and 2.1% had chromosomal translocation [5].
Can you get pregnant with balanced translocation?
Natural conception and live birth is possible in cases of balanced translocation, but those with the condition may have more difficulty conceiving and are at a greater risk of recurrent miscarriage than those without it.
What does chromosome translocation cause?
Translocations generate novel chromosomes, but are often linked to disorders like infertility and cancer. How do these new chromosomes generate problems, and how are they detected? Translocations generate novel chromosomes.
What is an example of translocation?
The term translocation is used when the location of specific chromosome material changes. The translocation in this example is between chromosomes 14 and 21. When a baby is born with this type of translocation chromosome in addition to one normal 14 and two normal 21 chromosomes, the baby will have Down syndrome.
What disease is caused by translocation mutation?
Role in disease Some human diseases caused by translocations are: Cancer: Several forms of cancer are caused by acquired translocations (as opposed to those present from conception); this has been described mainly in leukemia (acute myelogenous leukemia and chronic myelogenous leukemia).
What causes a translocation?
Translocation Down syndrome is a type of Down syndrome that is caused when one chromosome breaks off and attaches to another chromosome. In this case, there are three 21 chromosomes but one of the 21 chromosomes is attached to another chromosome.
Is Down syndrome caused by translocation?
Yes. Translocation Down Syndrome is the only type of Down Syndrome that can be passed down from a parent who does not have features of Down Syndrome. If a parent has balanced translocation, there is an up to 15% chance of having another child with Down Syndrome.
What is the translocation type of Down syndrome?
Translocation Down syndrome refers to the type of Down syndrome that is caused by rearranged chromosome material. In this case, there are three # 21 chromosomes, just like there are in trisomy 21, but one of the 21 chromosomes is attached to another chromosome, instead of being separate.