What are other names for hemophilia?
There are three major forms of inherited hemophilia: hemophilia A, also known as classical hemophilia, factor VIII deficiency or antihemophilic globulin [AHG] deficiency); hemophilia B, and hemophilia C, known as factor XI deficiency or Rosenthal’s disease.
What is the name of factor IX?
Factor IX (or Christmas factor) (EC 3.4.21.22) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1.
What is the scientific name for hemophilia?
Hemophilia A, also called factor VIII (8) deficiency or classic hemophilia, is a genetic disorder caused by missing or defective factor VIII (FVIII), a clotting protein.
What is factor IX used for?
Factor IX is a protein produced naturally in the body. It helps the blood form clots to stop bleeding. Injections of factor IX are used to treat hemophilia B, which is sometimes called Christmas disease.
What is Factor 9 in the blood?
Factor IX is a protein that helps your blood clot. If you are lacking this protein, you may have a bleeding disorder called hemophilia B. Hemophilia B is found mostly in males. When people with hemophilia get cut or injured, bleeding is hard to stop because their blood does not have normal clotting substances.
Why is Factor 9 called Christmas factor?
Hemophilia B is the second most common type of hemophilia. It is also known as factor IX deficiency, or Christmas disease. It was originally named “Christmas disease” after the first person diagnosed with the disorder back in 1952.
Why is hemophilia B Christmas?
Christmas disease, also called hemophilia B or factor IX hemophilia, is a rare genetic disorder in which your blood doesn’t clot properly. If you have Christmas disease, your body produces little or no factor IX. This leads to prolonged or spontaneous bleeding.
What is factor 10 called?
People with factor X (10) deficiency (sometimes called Stuart-Prower deficiency) have low levels of factor X in their blood. Factor X helps activate a protein called prothrombin (factor II), which is needed to form a stable blood clot.
What is factor 10 in blood coagulation?
Factor X. Factor X is a 58.8-kDa vitamin K-dependent glycoprotein that participates in the middle phase of blood coagulation. It is synthesized in the liver and secreted into the blood as a zymogen. Factor Xa cleaves prothrombin to thrombin in the presence of factor Va, calcium ions, and phospholipids [1].
What are the 12 clotting factors?
The following are coagulation factors and their common names:
- Factor I – fibrinogen.
- Factor II – prothrombin.
- Factor III – tissue thromboplastin (tissue factor)
- Factor IV – ionized calcium ( Ca++ )
- Factor V – labile factor or proaccelerin.
- Factor VI – unassigned.
- Factor VII – stable factor or proconvertin.
How is factor 12 activated?
In vivo, factor XII is activated by contact to polyanions. Contact to polyphosphates activates factor XII and initiates fibrin formation by the intrinsic pathway of coagulation with critical importance for thrombus formation.
What is factor 13 disorder?
Factor XIII deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. Signs and symptoms occur as the result of a deficiency in the blood clotting factor 13, which is responsible for stabilizing the formation of a blood clot.
Where does factor 12 come from?
Coagulation Factor XII (Hageman factor, FXII) is produced and secreted by the liver. It is the product of a single gene that maps to chromosome 5 [4]. The gene for Factor XII is 12kb and is composed of 13 introns and 14 exons [5].
Does thrombin activate factor 12?
Activated factor XII (XIIa) then activates FXI. Factor XI can also be activated by thrombin and this activation is essential for sustained thrombin generation during clot formation (Naito and Fujikawa, 1991). Thrombin cleaves zymogen factor XI to a serine protease (XIa).
Where is thrombin found?
The thrombin (prothrombin) gene is located on the eleventh chromosome (11p11-q12). There are an estimated 30 people in the world that have been diagnosed with the congenital form of Factor II deficiency, which should not be confused with the prothrombin G20210A mutation, which is also called the factor II mutation.
Is Thrombin a factor 2?
Prothrombin (factor II) is a soluble 72-kDa protein that is produced by the liver. It is activated to thrombin (factor IIa) via enzymatic cleavage of two sites by activated FX (FXa). Activated thrombin leads to cleavage of fibrinogen into fibrin monomers that, upon polymerization, form a fibrin clot.
Which enzyme is used in blood clotting?
Blood-clotting proteins generate thrombin, an enzyme that converts fibrinogen to fibrin, and a reaction that leads to the formation of a fibrin clot.
Which enzyme is used to dissolve?
Amylase is an enzyme secreted by the pancreas and salivary glands. It helps in the initial process of digestion.
Which hormone is responsible for blood clotting?
The new hormone, called thrombopoietin (pronounced throm-boh-POH-it-in), induces immature bone marrow cells to develop into platelets, the disk-shaped cells that help blood clot.