Can indomethacin cause liver damage?

Can indomethacin cause liver damage?

Drug induced liver injury from indomethacin is usually mild-to-moderate in severity and transient, but can progress to acute liver failure and death. In large case series, indomethacin is rarely mentioned as a cause of acute liver failure. Rechallenge may lead to recurrence and should be avoided.

What drugs cause severe hepatotoxicity?

The 10 most frequently implicated drugs were: amoxicillin-clavulanate, flucloxacillin, erythromycin, diclofenac, sulfamethoxazole/Trimethoprim, isoniazid, disulfiram, Ibuprofen and flutamide [12,13,14,21].

Which Nsaid causes hepatotoxicity?

Sulindac and diclofenac are the NSAIDs that are most commonly linked to hepatotoxicity, but virtually all NSAIDs that have been used extensively have been linked to at least rare cases of clinically apparent drug induced liver injury.

Which drugs can cause drug induced liver injury?

Other drugs that can lead to liver injury include:

  • Amiodarone.
  • Anabolic steroids.
  • Birth control pills.
  • Chlorpromazine.
  • Erythromycin.
  • Halothane (a type of anesthesia)
  • Methyldopa.
  • Isoniazid.

How is drug-induced liver injury treated?

Treatment of drug and herbal-induced liver injury consists of rapid drug discontinuation and supportive care targeted to alleviate unwanted symptoms. Adverse drug reactions are an important cause of liver injury that may require discontinuation of the offending agent, hospitalization, or even liver transplantation.

How can I reduce liver inflammation?

Here are a few foods to include in your healthy liver diet:

  1. Coffee to lower abnormal liver enzymes.
  2. Greens to prevent fat buildup.
  3. Tofu to reduce fat buildup.
  4. Fish for inflammation and fat levels.
  5. Oatmeal for energy.
  6. Walnuts to improve the liver.
  7. Avocado to help protect the liver.

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