What is a non-inferiority study? Active control trials aim to demonstrate that treatments of interest have either superior effects or similar effects to the control. If the intent of a study is to demonstrate that an experimental treatment is not substantially worse than a control treatment, the study is known as a noninferiority trial. How […]
What is non-inferiority?
What is non-inferiority? By definition, a non-inferiority trial aims to demonstrate that the test product is not worse than the comparator by more than a small pre-specified amount. This amount is known as the non-inferiority margin, or delta. Clinicians must know who has chosen the margin, and why. What is a non-inferiority design? What is […]
Can a non-inferiority trial show superiority?
Can a non-inferiority trial show superiority? In a non-inferiority trial, the focus is on the lower bound margin, what happens at the upper end is not of primary concern in this type of trial design. One can also declare superiority in a non-inferiority trial if the lower limit of CI of the new treatment is […]
What is a disadvantage of a within-subject experimental design?
What is a disadvantage of a within-subject experimental design? Fatigue is another potential drawback of using a within-subject design. Participants may become exhausted, bored, or simply uninterested after taking part in multiple treatments or tests. Finally, performance on subsequent tests can also be affected by practice effects. What is a between-subjects experiment? Between-subjects is a […]
What is a major advantage of a within-subjects design?
What is a major advantage of a within-subjects design? Advantages. The single most important advantage of a within-subjects design is that you do not have to worry about individual differences confounding your results because all treatment groups include the exact same partcipants. In what circumstances would you use the within-subjects design? Interference Effects and Learning […]
What can be used as basis for writing the research title?
Why the Declaration of Independence is important today?
Why the Declaration of Independence is important today? The Declaration of Independence is still important today because it signifies the birth of a nation, instructs free citizens and provides hope for all people who want to be free. The Declaration is the birth certificate of America. It also reminds us the reasons the United States […]
Which test is used in a repeated measures or within-subjects design?
Which test is used in a repeated measures or within-subjects design? repeated measures ANOVA Why is a repeated measures design considered a within-subjects design? Within-subjects designs control these individual differences by comparing the scores of a subject in one condition to the scores of the same subject in other conditions. Within-subjects designs are often called […]
What is a superiority trial?
What is a superiority trial? A superiority trial is designed to detect a difference between treatments. The first step of the analysis is usually a test of statistical significance to evaluate whether the results of the trial are consistent with the assumption of there being no difference in the clinical effect of the two treatments. […]
What makes a good nurse?
What makes a good nurse? A characteristic of a good nurse is one that shows empathy to each patient, making a true effort to put themselves in their patients’ shoes. By practicing empathy, nurses are more likely to treat their patients as “people” and focus on a person-centered care approach, rather than strictly following routine […]