How much Cymbalta is fatal?
Fatal overdoses of duloxetine have been reported with as little as 1,000 milligrams. Overdoses generally manifest with sleepiness, coma, serotonin syndrome, seizures, tachycardia, hyper or hypotension, and vomiting. Treatment should be supportive.
Can I take 90mg of Cymbalta?
Results from this study suggest that rapid dose escalation of duloxetine (60 mg/day –> 90 mg/day –> 120 mg/day) is safe and tolerable. Despite weekly escalation, the majority of adverse events were mild and transient and occurred in the first week of duloxetine dosing (at 60 mg once daily).
How much Cymbalta should I take for pain?
The recommended Cymbalta dose for treating chronic musculoskeletal pain* in adults is 60 mg once daily. You’ll start by taking 30 mg once daily for a week. Then, assuming you respond well to the drug, your doctor will increase your dose to 60 mg once daily.
Should I take Cymbalta in the morning or at night?
It is best to take Cymbalta (duloxetine) at the same time every day. Most people take it in the morning, but if you find that you feel drowsy after taking it in the morning, try taking it in the evening.
What does Cymbalta do to the brain?
Cymbalta inhibits the reuptake of serotonin and norepinephrine in the central nervous system. It also increases dopamine by acting on dopamine reuptake pumps, thus increasing the diffusion of dopamine in the brain.
Can Cymbalta help you lose weight?
Conclusion: Duloxetine-treated patients experienced weight loss after short-term treatment, followed by modest weight gain on longer-term treatment. The size of the weight changes observed suggests that the antidepressant duloxetine has minimal effects on weight for the majority of patients.
Is 60 mg of duloxetine a lot?
Adults—40 milligrams (mg) per day (given as 20 mg two times per day) to 60 mg per day (given either once a day or as 30 mg two times per day). Your doctor may increase your dose as needed. However, the dose is usually not more than 120 mg per day.
Which is better Cymbalta or Wellbutrin?
Wellbutrin (Bupropion) Improves mood and relieves certain types of pain. Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.
Is Duloxetine a safe drug?
Generally, duloxetine is safe and well-tolerated across indications, with few reported serious side effects. Common adverse events are consistent with the pharmacology of the molecule and are mainly referable to the gastrointestinal and the nervous systems.
What are the worst side effects of Cymbalta?
Nausea, dry mouth, constipation, loss of appetite, tiredness, drowsiness, or increased sweating may occur. If any of these effects persist or worsen, tell your doctor promptly. Dizziness or lightheadedness may occur, especially when you first start or increase your dose of this drug.