Is venlafaxine soluble in water?

Is venlafaxine soluble in water?

Venlafaxine hydrochloride is a white to off-white crystalline solid with a solubility of 572 mg/mL in water (adjusted to ionic strength o f 0.2 M with sodium chloride).

How do you dissolve venlafaxine?

Try to take at the same time each day. Swallow extended-release capsules whole; do not break, crush, or chew or attempt to dissolve in water. If you cannot swallow the capsule whole, the capsule may be opened and the contents sprinkled over a spoonful of applesauce and swallowed without chewing.

Why is venlafaxine a second line treatment?

It is usually reserved as a second-line treatment for depression due to a combination of its superior efficacy to the first-line treatments like fluoxetine, paroxetine and citalopram and greater frequency of side effects like nausea, headache, insomnia, drowsiness, dry mouth, constipation, sexual dysfunction, sweating …

Can venlafaxine be crushed?

Take venlafaxine exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor. Swallow the extended-release capsule whole; do not split, chew, or crush it, or place it in water.

What are the doses of venlafaxine?

The recommended starting dose for venlafaxine tablets, USP is 75 mg/day, administered in two or three divided doses, taken with food. Depending on tolerability and the need for further clinical effect, the dose may be increased to 150 mg/day. If needed, the dose should be further increased up to 225 mg/day.

Is venlafaxine for severe depression?

Based upon studies comparing venlafaxine with both placebo and other first-line antidepressants, it is concluded that venlafaxine is safe, tolerable, and effective for the treatment of severe depression.

Is 300 mg of venlafaxine a lot?

Dosage for major depressive disorder The usual starting dosage of Effexor XR for major depressive disorder (MDD) is 75 mg once daily. The maximum dosage for MDD is 225 mg once daily. However, daily dosages of 300 mg or higher may be needed to treat MDD in some people.