What genre best describes Freak the Mighty?
Freak the Mighty
| First edition | |
|---|---|
| Author | Rodman Philbrick |
| Genre | Young Adult fiction |
| Publisher | Blue Sky/Scholastic |
| Publication date | 1993 |
Is Freak the Mighty fiction or nonfiction?
While Freak the Mighty is technically a fiction novel, it was written for a very specific group of readers. Freak the Mighty is considered a party of the young adult fiction genre, a literary collection geared towards readers ages 12 to 18.
What is wrong with freak?
Freak suffers from a genetic disorder called Morquio syndrome. People with Morquio Syndrome are unable to break down a special type of sugars called glycosaminoglycans. Freak’s disorder is a main part of the plot in Freak the Mighty and helps drive major conflicts in the book.
Is Morquio syndrome rare?
Morquio syndrome is a rare genetic condition that affects a child’s bones and spine, organs and physical abilities. Children with this condition are missing or don’t produce enough of the enzymes that break down sugar chains naturally produced in the body.
What are the 2 types of Morquio syndrome?
Morquio syndrome is classified into two types, Morquio A syndrome (mucopolysaccharidosis type IVA [MPS IVA]; OMIM 253000) and Morquio B syndrome (mucopolysaccharidosis type IVB [MPS IVB]; OMIM 253010), based on a deficiency of different lysosomal enzymes—N-acetylgalactosamine-6-sulfate sulfatase (GALNS) and β- …
What is the survival rate of Morquio syndrome?
| Morquio syndrome | |
|---|---|
| Causes | Inherited deficiency of enzymes |
| Treatment | Elosulfase alfa (Vimizim) for Type A; no approved treatment for Type B |
| Prognosis | Reduced lifespan. Usually death occurs in 20s to 30s |
| Frequency | 1 in 200,000 to 1 in 300,000 |
What is Fabry’s Disease?
Fabry disease is an inherited disorder that results from the buildup of a particular type of fat, called globotriaosylceramide, in the body’s cells. Beginning in childhood, this buildup causes signs and symptoms that affect many parts of the body.
Is Fabry disease rare?
Fabry disease is a rare genetic disease and symptoms that affect the kidneys, heart, or brain most often occur when patients are age 30 to 45 years. Fabry disease is a rare genetic disease with a deficiency of an enzyme called alpha-galactosidase A.
Can Fabry disease be cured?
There is no cure for Fabry disease. Recombinant alpha-galactosidase A (alpha-Gal A), the enzyme that is deficient in patients with Fabry disease, and migalastat hydrochloride, an oral pharmacologic chaperone that facilitates trafficking of alpha-Gal A to lysosomes, are therapeutic options for eligible individuals.
How long is the average lifespan of a person with Fabry disease?
Published data from the Fabry registry indicates that male Fabry disease patients live an average of about 58 years, compared to about 75 years for men in the general population in the U.S. For women with Fabry disease, the average life expectancy is around 75 years compared to 80 years for women in the U.S. general …
What age is Fabry disease diagnosed?
The median age at diagnosis of Fabry disease was 28.6 years in a recent study from Australia [3]. Similarly, the median age at diagnosis was about 28 years among 688 patients recorded in FOS – the Fabry Outcome Survey – although the first symptoms occurred some 16 years earlier (Table 1).
How do you know if you have Fabry disease?
What are the symptoms of Fabry disease?
- Numbness, tingling, burning or pain in the hands or feet.
- Extreme pain during physical activity.
- Heat or cold intolerance.
- Abnormal opacity of the eye (cornea), which does not change someone’s vision.
- Dizziness.
- Flu-like symptoms, including fatigue, fever and body aches.
What is Gaucher disease?
Gaucher disease is a rare genetic disorder passed down from parents to children (inherited). When you have Gaucher disease, you are missing an enzyme that breaks down fatty substances called lipids. Lipids start to build up in certain organs such as your spleen and liver.
What age is Gaucher disease diagnosed?
Although the disease can be diagnosed at any age, half of patients are under the age of 20 at diagnosis. The clinical presentation is heterogeneous with occasional asymptomatic forms.
What organs does Gaucher disease affect?
It is a disorder passed from parents to children (inherited). It causes fatty substances called lipids to build up in organs such as the spleen and liver. Organs can become very large and not work well. It can also affect the lungs, brain, eyes, and bones.