What inspired Rodman?
Inspired by the life of a boy who lived a few blocks away, he wrote ‘Freak The Mighty’, the award-winning young-adult novel, which has been translated into n. Philbrick. Rodman Philbrick grew up on the New England coast, where he worked as a longshoreman and boat builder. Writing under the pen name ‘William R.
When did Rodman Philbrick start writing?
I started writing when I was about 12. I managed to finish a novel-length piece when I was 16 — although it was another 12 years before I finally got a book published!
What does a person with Morquio Syndrome look like?
Symptoms of Morquio syndrome include: Short stature, with a very short torso. Abnormal bone and spine development, including severe scoliosis. Bell-shaped chest with ribs flared out at the bottom.
What is Hunter’s syndrome?
Hunter syndrome is a rare, inherited disorder in which the body does not properly digest (break down) sugar molecules in the body. When these molecules build up in organs and tissues over time, they can cause damage that affects physical and mental development and abilities.
Can a female have Hunter’s Disease?
Hunter syndrome nearly always occurs in males. Girls are far less at risk of developing this disease because they inherit two X chromosomes. If one of the X chromosomes is defective, their normal X chromosome can provide a functioning gene.
At what age is Sanfilippo Syndrome diagnosed?
Children with Sanfilippo syndrome do not usually show symptoms from birth. They typically begin to show symptoms of the condition during early childhood, from the ages of about one to three years old. Symptoms will get progressively worse over time.
How did Hunter’s syndrome get its name?
MPS II (Hunter Syndrome) MPS II is a mucopolysaccharide disease known as Hunter syndrome. It takes its name from Charles Hunter, the professor of medicine in Manitoba, Canada, who first described two brothers with the disease in 1917.
What is the life expectancy of someone with MPS?
For example, individuals with the mildest form of MPS I (MPS IS) may have a reasonably normal lifespan, while those with intermediate (MPS IH/S) usually live to teen age or early adulthood. Those with severe MPS I (MPS IH or Hurler syndrome) rarely live longer than 10 years.
What type of mutation causes Hunter’s syndrome?
A New Mutation in IDS Gene Causing Hunter Syndrome: A Case Report. Rationale: Mucopolysaccharidosis type II (Hunter syndrome) is an X-linked multisystem disorder, caused by deficiency of the lysosomal enzyme iduronate-2-sulfatase (I2S).
What enzyme is deficient in Hurler syndrome?
Hurler syndrome (mucopolysaccharidosis type 1-H; MPS 1-H) is the most severe form of mucopolysaccharidosis. It is characterized by a deficiency of the enzyme alpha-L-iduronidase, which results in an accumulation of dermatan and heparan sulfates.