What is a normal tTG IgA level?
To determine if undetectable levels (<1.2 U/mL) of tTG IgA carry a different prognosis compared with normal but detectable levels (1.2–4.0 U/mL), investigators retrospectively assessed mucosal healing in 402 patients with celiac disease who had a tTG IgA level <4 U/L determined within 1 month of a small bowel biopsy.
What is a positive tTG IgA result?
The finding of tissue transglutaminase (tTG)-IgA antibodies is specific for celiac disease and possibly for dermatitis herpetiformis. For individuals with moderately to strongly positive results, a diagnosis of celiac disease is likely and the patient should undergo biopsy to confirm the diagnosis.
What is normal range for celiac?
Celiac Disease Diagnostics Panel
| Age | Reference Range |
|---|---|
| 9-11 years | 33-200 mg/dL |
| 12-16 years | 36-220 mg/dL |
| 17-60 years | 47-310 mg/dL |
| 61 years or older | 70-320 mg/dL |
What is high IgA indicative of?
High values Levels of IgA also get higher in some autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus (SLE), and in liver diseases, such as cirrhosis and long-term (chronic) hepatitis. IgG. High levels of IgG may mean a long-term (chronic) infection, such as HIV, is present.
What does IgA test for?
An IgA test measures the blood level of immunoglobulin A, one of the most common antibodies in the body. Antibodies are proteins made by the immune system to fight bacteria, viruses, and toxins.
Where is IgA normally found?
Immunoglobulin A (IgA): It’s found in the linings of the respiratory tract and digestive system, as well as in saliva (spit), tears, and breast milk. Immunoglobulin G (IgG): This is the most common antibody.
What stimulates IgA production?
In particular, TLR5-expressing DCs highly responsive to bacterial flagellin (a TLR5 ligand) induce IgA production by stimulating B cells through IL-6 and RA (95). In addition to promoting plasma cell differentiation, RA enhances both IgA CSR and production by cooperating with TGF-β (59, 96).
Why is IgA important?
Immunoglobulin A (IgA), as the principal antibody class in the secretions that bathe these mucosal surfaces, acts as an important first line of defence. IgA, also an important serum immunoglobulin, mediates a variety of protective functions through interaction with specific receptors and immune mediators.
What is the main function of secretory IgA?
Secretory IgA is the principal weapon protecting us from pathogens and toxins that might otherwise penetrate mucosal surfaces. These antibodies, whose expression was discussed in Chapter 5, are key components of the mucosal mucus and other body secretions such as saliva and tears.
Why is my secretory IgA high?
High levels of SIgA Elevated levels in saliva are associated with an immune response to stimulation by infections and inflammatory reactions. High levels of SIgA production may indicate an infection of the digestive system, in which case a Comprehensive Stool Analysis with parasites would be recommended.