What is the most mineralized tissue in the body?

What is the most mineralized tissue in the body?

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Which is the major organic component in mineralized bone tissue?

Modified (flattened) osteoblasts become the lining cells that form a protective layer on the bone surface. The mineralized matrix of bone tissue has an organic component of mainly collagen called ossein and an inorganic component of bone mineral made up of various salts.

What is mineralized collagen?

Mineralized collagen is the building block for various connective tissues such as bone, cartilage, tendon, and dentin [1,2,3]. Extracellular bone matrix contains 60 wt % to 70 wt % mineral components in the form of nano-sized apatite crystals, 20 wt % to 30 wt %collagen fibers, and 10 wt % to 20 wt % water [4].

What is matrix mineralization?

2.1 Collagen Matrix Organization Bone mineralization, the process by which the organic bone matrix becomes filled with calcium phosphate nanocrystals, occurs in a specific, highly ordered process. The process is mediated by osteoblasts and confined to the organic osteoid matrix produced by osteoblasts.

Is bone mineralization bad?

As a consequence, the quality of bone tissue can be compromised. Such pathological bone mineralization can be the main cause of many bone diseases. Osteomalacia is a metabolic bone disease caused by lack of bone mineral or overactive bone resorption in adults.

Is calcification the same as mineralization?

Vascular calcification is an active cell-regulated process in which mineralization is the net result of a transdifferentiation process of vascular smooth muscle cells to chondrocyte-like or osteoblast-like cells.

What causes bone mineralization?

Dysfunctions in tubular phosphate reabsorption via the sodium-phosphate cotransporter, endocytotic reabsorption of the vitamin D–vitamin D–binding protein complex mediated by megalin and cubilin, and acid-base regulation are the most important factors that cause bone mineralization defects in these patients.

Which vitamin is required for normal bone mineralization?

About Vitamin D Vitamin D helps the body absorb calcium in the gut, aids bone growth and remodeling, and maintains correct calcium and phosphorus serum levels to sustain normal bone mineralization. As a bonus, Vitamin D is linked to proper immune function, reduction of inflammation, and better emotional health.

Why are people with dark skin a risk of vitamin D deficiency?

Vitamin D deficiency is not common. Some people are at greater risk of vitamin D deficiency including: People with naturally very dark skin. This is because the pigment (melanin) in dark skin doesn’t allow the skin to absorb as much UV radiation.

Is osteoporosis caused by vitamin D deficiency?

The consequences of vitamin D deficiency are secondary hyperparathyroidism and bone loss, leading to osteoporosis and fractures, mineralization defects, which may lead to osteomalacia in the long term, and muscle weakness, causing falls and fractures.

Can vitamin D deficiency reversed symptoms?

You can reverse vitamin D deficiency over time by getting enough vitamin D. Take your prescribed dose of vitamin D and keep appointments with your doctor, to ensure the success of your treatment and healthy bones.

How much Vit D should a woman with osteoporosis take?

Due to the relative lack of vitamin D-containing foods, supplements of vitamin D are often necessary to achieve an adequate intake. The National Osteoporosis Foundation (NOF) recommends an intake of 800 to 1000 international units (IU) of vitamin D3 per day for adults over age 50 (NOF 2008).

What is the best vitamin D for osteoporosis?

There are two types of vitamin D supplements. They are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Both types are good for bone health.

Does Vitamin D Help Osteoporosis?

Vitamin D helps the body absorb calcium and phosphorus from the food you eat. So the nutrient is important for people with osteoporosis. Studies show that calcium and vitamin D together can build stronger bones in women after menopause. It also helps with other disorders that cause weak bones, like rickets.

What is the best vitamin for osteopenia?

The main ones are calcium and vitamin D supplements. Most adults should get between 1,000 and 1,200 milligrams of calcium and 600 to 800 international units (IU) of vitamin D every day….Natural Treatments for Osteopenia

• Folic acid, vitamin B6, and vitamin B12.
• Manganese.
• Silicon.
• Strontium.
• Zinc.