Why atropine is used in glaucoma?
Atropine causes the muscles in your eye to become relaxed. This widens (dilates) your pupil so that it will not respond to light. Atropine ophthalmic (for the eye) is used to dilate your pupils when you have an inflammatory condition or in postsurgery situations in which this effect may be helpful.
Why are anticholinergics contraindicated in glaucoma?
Anticholinergics inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells. This can cause glaucoma in individuals with narrow anterior chamber angles by dilating the pupil and causing pupillary block.
Does atropine lower eye pressure?
Intraocular pressure and pupil diameter were measured prior to and during a 2-day period of treatment with 1% atropine sulfate. No significant changes in intraocular pressure occurred as a result of the treatment with atropine. Pupil diameter increased significantly after atropine was applied.
Does atropine treat glaucoma?
The condition may recur when therapy is decreased. Atropine may be required indefinitely to prevent recurrences. Bimatoprost, travoprost, tafluprost, and latanoprost are effective new medications for lowering intraocular pressure in patients with glaucoma and ocular hypertension.
Does atropine raise blood pressure?
However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure. Systemic doses slightly raise systolic and lower diastolic pressures and can produce significant postural hypotension.
Does atropine increase heart rate?
Atropine increases the heart rate and improves the atrioventricular conduction by blocking the parasympathetic influences on the heart.
Does atropine work on heart transplant?
Cardiac denervation effects After a heart transplant, patients will also have no response of heart rate to carotid sinus massage or drugs such as atropine, which act by blocking the action of acetylcholine at parasympathetic sites.
Who should not take atropine?
Additionally, the antimuscarinic actions of atropine may cause urinary retention and should be avoided in patients with prostatic hypertrophy, bladder obstruction, or urinary tract obstruction.
What is atropine mechanism of action?
Mechanism of action. The most important therapeutic action of atropine is the inhibition of smooth muscle and glands innervated by postganglionic cholinergic nerves. It also has central nervous system activity, which may be stimulating or depressing depending upon the dose.