Why does irinotecan cause diarrhea?

Why does irinotecan cause diarrhea?

Irinotecan can cause acute diarrhea (immediately after drug administration) or delayed diarrhea. Immediate-onset diarrhea is caused by acute cholinergic properties and is often accompanied by other symptoms of cholinergic excess, including abdominal cramping, rhinitis, lacrimation, and salivation.

Does irinotecan cause neutropenia?

Introduction. Irinotecan (CPT-11), a topoisomerase I inhibitor, is commonly used for the treatment of colorectal, gastric, and lung cancer. Although irinotecan is efficient, it causes severe neutropenia and diarrhea in 20–35% of the patients1,2.

Why do chemotherapy drugs cause diarrhea?

Some chemotherapy drugs irritate the lining of your digestive system. So diarrhoea is a common side effect. It usually comes on in the first few days after each treatment. Some drugs can cause severe diarrhoea.

Which of the following increases a patient’s risk for diarrhea following chemotherapy?

These include medications (e.g. stool softeners, laxatives, antacids, etc), infection by C. difficile or Candida species, partial bowel obstruction, malabsorption, fecal impaction, acute radiation reaction and surgery (short bowel syndrome). Diets high in fiber or lactose may aggravate diarrhea.

What is the most common side effect of docetaxel?

The most common adverse reactions across all TAXOTERE indications are infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin …

Is it normal to have diarrhea after chemotherapy?

Some chemotherapy drugs may cause digestive upsets, including nausea, vomiting, constipation, and diarrhea. Many women will experience a change in bowel movements, including an increase or decrease in frequency, during their treatment. Diarrhea is a common side effect.

How do you cure your diarrhea after chemo?

What can you do?

1. Drink clear liquids. As soon as your diarrhea starts, switch to a diet of clear liquids, such as water, apple juice, clear broth and ice pops.
2. Eat low-fiber foods.
3. Eat five to six small meals a day.
4. Avoid foods that can irritate your digestive tract.
5. Try probiotics.